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Article: New data from University of Linz illuminate research in biological chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 13, 2009
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"STIM1 and ORAI1, the two limiting components in the Ca2+ release-activated Ca2+ (CRAC) signaling cascade, have been reported to interact upon store depletion, culminating in CRAC current activation. We have recently identified a modulatory domain between amino acids 474 and 485 in the cytosolic part of STIM1 that comprises 7 negatively charged residues," researchers in Linz, Austria report.
"A STIM1 C-terminal fragment lacking this domain exhibits enhanced interaction with ORAI1 and 2-3-fold higher ORAI1/CRAC current densities. Here we focused on the role of this CRAC modulatory domain (CMD) in the fast inactivation of ORAI1/CRAC channels, utilizing the ...
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Article: Bombardier to Supply 23 FLEXITY Outlook Trams to Linz, ...
M2 Presswire;
July 6, 2009 ;
700+ words
... ... Bombardier to Supply 23 FLEXITY Outlook Trams to Linz, Austria(C)1994-2009 M2 COMMUNICATIONS ... from the Austrian transport operator, LINZ LINIEN GmbH to supply 23 BOMBARDIER FLEXITY ... 97 million US). With this order, Linz has once again opted for Bombardier's ...
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