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Article: Findings from Y.F. Wei and co-authors provide new insights into bioconjugate chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 13, 2009
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According to a study from Calcutta, India, "TAT peptide functionalized shell-core ZnS-CdSe quantum dots (QDs) have been prepared by three different methods, direct ligand exchange with cysteine-terminated TAT (TAT-QD(lig) (exch)), and covalent conjugation to QDs coated with silanes (TAT-QD(silica)) and polyacrylate derivatives (TAT-QD(polyacrylate)). The silica and polyacrylate coatings incorporated multiple primary and secondary amines, introducing positive surface charges onto the QDs, providing high water solubility and sites for peptide Conjugation, while inducing the ''proton sponge effect'."
"The different coating methods produced particles of different ...