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Article: Research reports from University of Munich provide new insights into bioconjugate chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 13, 2009
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"Various pathogenic processes are driven by protein(lectin)-glycan interactions. especially involving beta-galactosides at branch ends of cellular glycans. These emerging insights fuel the interest to design potent inhibitors to block lectins," scientists in Munich, Germany report.
"As a step toward this aim, we prepared a series of ten mono- to tetravalent glycocompounds with lactose as a common headgroup. To obtain activated carbonate for ensuing carbamate formation, conditions for the facile synthesis of pure isomers from anomerically unprotected lactose were identified. To probe for the often encountered intrafamily diversity of human lectins, we selected ...