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Article: Research on biological chemistry published by scientists at University of Cologne.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 13, 2009
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"The Arabidopsis thaliana locus At5g06580 encodes an ortholog to Saccharomyces cerevisiae D-lactate dehydrogenase (AtD-LDH). The recombinant protein is a homodimer of 59-kDa subunits with one FAD per monomer," scientists in Cologne, Germany report.
"A substrate screen indicated that AtD-LDH catalyzes the oxidation of D-and L-lactate, D-2-hydroxybutyrate, glycerate, and glycolate using cytochrome c as an electron acceptor. AtD-LDH shows a clear preference for D-lactate, with a catalytic efficiency 200- and 2000-fold higher than that for L-lactate and glycolate, respectively, and a Km value for D-lactate of similar to 160 mc M. Knock-out mutants showed impaired ...
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