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Article: Research from S. Kindler and co-researchers provides new data on biological chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 13, 2009
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"Jacob is a recently identified plasticity-related protein that couples N-methyl-D-aspartate receptor activity to nuclear gene expression. An expression analysis by Northern blot and in situ hybridization shows that Jacob is almost exclusively present in brain, in particular in the cortex and the limbic system," scientists in Magdeburg, Germany report.
"Alternative splicing gives rise to multiple mRNA variants, all of which exhibit a prominent dendritic localization in the hippocampus. Functional analysis in primary hippocampal neurons revealed that a predominant cis-acting dendritic targeting element in the 3'-untranslated region of Jacob mRNAs is responsible ...