|
|
Article: New biological chemistry study findings recently were reported by researchers at University of Oxford.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 13, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
"Communication between the cell surface and the nucleus is essential for regulated gene expression. In neurons, Ca2+-dependent gene transcription is sensitive to local Ca2+ entry," scientists in Oxford, the United Kingdom report.
"In immune cells, excitation-transcription coupling is thought to involve global Ca2+ signals. Here, we show that in mast cells, Ca2+ microdomains from store-operated Ca2+ release-activated Ca2+ channels activate expression of the transcription factor c-fos. Local Ca2+ entry is sensed by the tyrosine kinase Syk, which signals to the nucleus through the transcription factor STAT5. Ca2+ microdomains also promote secretion of ...
Related newspaper, magazine, and journal articles:
|
|
Article: New biological chemistry study findings have been ...
Chemicals & Chemistry;
June 12, 2009 ;
700+ words
... ... in the Journal of Biological Chemistry (Differential Clathrin ... Isoforms. Journal of Biological Chemistry, 2009;284(15 ... Michael Smith Bldg, Oxford Rd., Manchester ... for the Journal of Biological Chemistry is: American Society ...
|
|