Article: Research from Purdue University in the area of physical chemistry described.

"We demonstrate a surface-enhanced Raman spectroscopy (SERS) based array platform to monitor gene expression in cancer cells in a Multiplex and quantitative format without amplification steps. A strategy comprising DNA/RNA hybridization, SI nuclease digestion, and alkaline hydrolysis was adopted to obtain DNA targets specific to two splice junction variants, Delta(9, 10) and Delta(5), of the breast cancer susceptibility gene 1 from MCF-7 and MDA-MB-231 breast cancer cell lines," scientists in the United States report.

"These two targets were identified simultaneously, and their absolute quantities were estimated by a SERS strategy utilizing the inherent ...

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