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Article: Study data from S.K. Panday et al provide new insights into medicinal chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 13, 2009
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According to recent research from Bareilly, India, "Angiotensin converting enzyme (ACE) inhibitors have emerged as a revolution in antihypertensive therapy."
"of captopril, the first rationally designed ACE inhibitor, has encouraged researchers all over the world to design and synthesize target molecules controlling hypertension based on these lines. It has been observed that replacing proline part of captopril with 4-substituted prolines or 5-oxo-prolines led to significant enhancement in ACE inhibitory activity, and this observation prompted us to design and synthesize N-acyl 4-substituted pyroglutamates and prolinates with the objective of developing ...