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Article: New findings from Center for Satellite Applications and Research describe advances in cell biology.
- Article from:
- Science Letter
- Article date:
- November 10, 2009
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"p53 is a major tumor suppressor protein, that binds to, and is negatively regulated by MDM2. In tumors overexpressing MDM2, p53 function can be rescued through the disruption of the MDM2-p53 interactions by small molecules and peptides," scientists writing in the journal Cell Cycle report (see also Cell Biology).
"It is known that MDM2 also binds p73 but not p63, the two homologues of p53. We dissect the structural and energetic reasons underlying this discrimination and have identified a peptide that is intrinsically less helical than p53 and yet has a higher affinity for MDM2. The increased disorder has been introduced by localizing a cationic residue in ...