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Article: Investigators at University of Oregon zero in on cell biology.
- Article from:
- Science Letter
- Article date:
- November 10, 2009
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According to recent research from the United States, "Asymmetric cell division is intensely studied because it can generate cellular diversity as well as maintain stem cell populations. Asymmetric cell division requires mitotic spindle alignment with intrinsic or extrinsic polarity cues, but mechanistic detail of this process is lacking."
"Here, we develop a method to construct cortical polarity in a normally unpolarized cell line and use this method to characterize Partner of Inscuteable ( Pins; LGN/AGS3 in mammals) -dependent spindle orientation. We identify a previously unrecognized evolutionarily conserved Pins domain ( Pins LINKER) that requires Aurora-A ...