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Article: DNA Immunization With Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination.
- Article from:
- Immunotherapy Weekly
- Article date:
- June 29, 1998
CopyrightCOPYRIGHT 1998 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Rodriguez, F.; An, L.L.; Harkins, S.; Zhang, J.; Yokoyama, M.; Widera, G.; Fuller, J.T.; Kincaid, C.; Campbell, I.L.; Whitton, J.L. "DNA Immunization With Minigenes: Low Frequency of Memory Cytotoxic T Lymphocytes and Inefficient Antiviral Protection Are Rectified by Ubiquitination." Journal of Virology, June 1998;72(6):5174-5181.
According to the authors' abstract of an article published in Journal of Virology, "Our previous studies have shown that isolated cytotoxic T-lymphocyte (CTL), B-cell, and T-helper epitopes, for which we coined the term minigenes, can be effective vaccines; when expressed from recombinant vaccinia viruses, these short immunogenic sequences ...