|
|
Article: Research from M.M. Pietzak and co-authors reveals new findings on celiac disease.(Report)
- Article from:
- Biotech Week
- Article date:
- November 18, 2009
CopyrightCOPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
"Susceptibility to celiac disease (CD) is related to HLA-DQ2 and DQ8 alleles and the heterodimers they encode. The objective of this study was to stratify risk For CD on the basis of HLA-DQ genotype," scientists in the United States report (see also Celiac Disease).
"DNA from 10,191 Subjects who are at risk for CD was analyzed for HLA-DQ haplotypes. individuals with CD were identified as those who rested positive for anti-endomysial immunoglobulin A (EMA+) in an immunofluorescence assay. Samples homozygous for DQ2.5 (HLA-DQA1*05-DQB1*02) or DQ2.2/DQ2.5 (HLA-DQA1*05-DQB1*02 and HLA-DQA1*0201-DQB1*02) comprised 5.38% of the total; 28.28% of these were EMA+ (95% ...