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Article: Reports outline DNA research from Indiana University.(Report)
- Article from:
- Biotech Week
- Article date:
- November 18, 2009
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According to a study from the United States, "In adult non-replicating tissues such as heart, demand for dNTPs (deoxynucleoside triphosphates) is low but essential for mitochrondrial DNA replication and nuclear DNA repair. dNTP`s may be synthesized from salvage of deoxyribonucleosides or by reduction of ribonucleotides. We have hypothesized that the cardiac mitochondrial toxicity of the nucleoside analogue AZT (3'-azido-3'-deoxythymidine; known as zidovudine) is caused by inhibition of thymidine kinase 2 of the salvage pathway and subsequent TTP pool depletion."
"The extent to which this hypothesis has merit depends on how much the heart relies on thymidine ...
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Article: Study findings from Indiana University, Walther ...
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