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Article: Research results from Texas A&M University update understanding of chemical biology.(Report)
- Article from:
- Chemicals & Chemistry
- Article date:
- November 20, 2009
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According to a study from the United States, "This study was initiated to find small molecule ligands that would induce a functional,response when docked with neurotrophin Trk receptors. ''Minimalist'' mimics of P-turns were designed for this purpose. These mimics are (i) rigid, yet easily folded into turn-like conformations, and (ii) readily accessible from amino acids bearing most of the natural side chains."
"Gram quantities of 16 of these, turn mimics were prepared and then assembled into 152 fluorescein-labeled bivalent peptidomimetics via a solution-phase combinatorial method. Fluorescence-based screening of these molecules using cells transfected with the, ...