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Article: Research from University of Oxford has provided new data on biological chemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 20, 2009
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"Signal-regulatory protein alpha (SIRP alpha) is a myeloid membrane receptor that interacts with the membrane protein CD47, a marker of self. We have solved the structure of the complete extracellular portion of SIRP alpha,comprising three immunoglobulin superfamily domains, by x-ray crystallography to 2.5 angstrom resolution," scientists in Oxford, the United Kingdom report.
"These data, together with previous data on the N-terminal domain and its ligand CD47 (possessing a single immunoglobulin superfamily domain), show that the CD47-SIRP alpha interaction will span a distance of around 14 nm between interacting cells, comparable with that of an immunological ...
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