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Article: Data on biological chemistry detailed by researchers at Hospital for Sick Children.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 20, 2009
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"Notch is a transmembrane receptor that controls cell fate decisions during development and tissue homeostasis. Both activation and attenuation of the Notch signal are tightly regulated by endocytosis," researchers in Toronto, Canada report.
"The adaptor protein Numb acts as an inhibitor of Notch and is known to function within the intracellular trafficking pathways. However, a role for Numb in regulating Notch trafficking has not been defined. Here we show that mammalian Notch1 is constitutively internalized and trafficked to both recycling and late endosomal compartments, and we demonstrate that changes in Numb expression alter the dynamics of Notch1 ...