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Article: Study data from Vanderbilt University, Medical Department provide new insights into radiopharmaceuticals.

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Drug Week
Article date:
November 20, 2009
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"A novel series of iodinated indomethacin derivatives was synthesized, and evaluated as selective inhibitors of COX-2. Two candidate compounds N-(p-iodobenzyl)-2-(1-(p-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetamide (3) and 1-(p-iodobenzyl)-5-methoxy-2-methyl-3-indoleacetic acid (9) possessed optimum properties suitable for potential in vivo imaging," researchers in the United States report (see also Radiopharmaceuticals).

"Arylstannane precursors for radioiododestannylation were synthesized in 70-85% yield from the iodo compounds by reaction with hexabutylditin and tetrakis(triphenylphosphine)palladium(0) in refluxing dioxane. Radioiododestannylation ...

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