Article: New findings from J. Muck and co-authors in the area of DNA research published.

"Replication foci are the units of DNA replication in the nucleus. They harbor the replication machinery and activereplicons," scientists in Singapore, Singapore report (see also DNA Research).

"Spooling of individual replicons appears to occur at replication foci of budding yeast. The dynamics associated with fork progression in mammalian nuclei are largely unclear but large-scale spooling of DNA does not occur. Replication foci are arranged into spatio-temporal higher-order patterns. Different kinds of such patterns have been observed in different eukaryotic taxa but the characteristic patterns observed in mammals are highly conserved. The changes of ...

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