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Article: Scientists at University of Sherbrooke publish new data on prion disease.
- Article from:
- Obesity, Fitness & Wellness Week
- Article date:
- November 21, 2009
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"Since it was posited that a cytoplasmic isoform of PrP may be involved in prion diseases, controversies about the isoform's biogenesis and function have emerged in the literature. While the existence of cytoplasmic PrP in vivo and in different cell cultures systems has now been well-established, whether it has specific activity remains unknown," scientists in Sherbrooke, Canada report (see also Prion Disease).
"This review outlines recent evidence about the molecular activity of cytoplasmic PrP. Cytoplasmic PrP inhibits a normal cellular stress response by preventing the assembly of protective mRNA stress granules and the synthesis of heat-shock protein 70 ...