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Article: New findings from Technical University of Dresden in the area of antioxidants and redox signaling published.(Report)
- Article from:
- Science Letter
- Article date:
- November 17, 2009
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According to recent research published in the journal Antioxidants & Redox Signaling, "Endothelial cells in vivo are constantly exposed to mechanical forces such as cyclic strain. In endothelial cells, Nox4-containing NAD(P)H oxidase complexes have been identified as major sources of superoxide anion (center dot O-2(-)) formation."
"In this study, we analyzed the effect of cyclic strain on endothelial ROS formation by electron paramagnetic resonance spectroscopy, cytochrome c assay, and dihydroethidium fluorescence, on NO formation by Griess reaction and on gene expression by RT-PCR and Western blot. Primary cultures of human umbilical vein endothelial cells were ...