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Article: Gene Delivery Senut, M.C.; Suhr, S.T.; Gage, F.H. "Gene Transfer to the Rodent Placenta in situ - A New Strategy for Delivering Gene Products to the Fetus." Journal of Clinical Investigation, April 15, 1998;101(8):1565-1571.
- Article from:
- Gene Therapy Weekly
- Article date:
- June 1, 1998
CopyrightCOPYRIGHT 1998 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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According to the authors' abstract of an article published in Journal of Clinical Investigation, "The delivery of biologically active factors to the developing mammalian embryo by in utero gene transfer has generated considerable interest but limited success. The chorioallantoic placenta is a potential alternative target for providing therapeutic transgenes to the fetus during gestation. We demonstrate that somatic gene transfer to the midgestation rat placenta may be efficiently accomplished in situ through the implantation of a variety of genetically modified cells with different antigenic and growth properties. Ex vivo-modified cells survived and ...
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