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Article: HSV-1 IgG Fc Receptor Blocks Effectiveness of Antibodies
- Article from:
- Vaccine Weekly
- Article date:
- August 24, 1998
CopyrightCOPYRIGHT 1998 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Study results may help explain why antibodies do not successfully modify herpes simplex virus (HSV) infection.
HSV glycoproteins gE and gI form an immunoglobulin G (IgG) Fc receptor (FcgammaR) that binds the Fc domain of human anti-HSV IgG and inhibits Fc-mediated immune functions in vitro. gE or gI deletion mutant viruses are avirulent, and this has made it difficult to investigate the role of HSV-1 FcgammaR in pathogenesis.
To modify FcgammaR activity without affecting other gE functions, Thandavarayan Nagashunmugam and colleagues, University of Pennsylvania, constructed a mutant virus, NS-gE[339], that has four amino acids inserted into gE within the domain ...