|
|
Article: Cancer Vaccines Taniguchi, F.; Yamagishi, H.; Fujiwara, H.; Ueda, Y.; Fuji, N.; Yoshimura, T.; Oka, T. "Systemic Administration of rIL-12 Synergistically Enhances the Therapeutic Effect of a TNF Gene-Transduced Cancer Vaccine." Gene Therapy, December 1998;5(12):1677-1684.
- Article from:
- Gene Therapy Weekly
- Article date:
- January 11, 1999
CopyrightCOPYRIGHT 1999 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
According to the authors' abstract of an article published in Gene Therapy, "Interleukin-12 (IL-12) is a potent antitumor cytokine, which induces and enhances the activity of natural killer (NK) cells, lymphokine activated killer (LAK) cells, and cytotoxic T lymphocytes (CTL). IL-12 also stimulates IFN-gamma production from both T cells and NK cells. In this study, we transfected methylcholanthrene-induced fibrosarcoma (MCA-D) with TNF gene and investigated the therapeutic effect of TNF gene-transduced cancer vaccine and whether the vaccination effect is enhanced by systemic administration of recombinant IL-12 (rIL-12) in a murine model. TNF gene-transduced cancer ...
Related newspaper, magazine, and journal articles:
|
|
Article: Researchers from Epeius Biotechnologies Corporation detail ...
Cancer Vaccine Week;
October 27, 2008 ;
700+ words
... ... CSF protein. In tumor-bearing nude mice, intravenous infusions of Reximmune-C-induced GM-CSF production by transduced cancer cells and paracrine secretion of the cytokine within the tumor nodules, which promoted the recruitment of host mononuclear ...
|
|