Article: Seeing and Treating Cholinergic Deficits in AD.(Alzheimer's disease)

ABSTRACTS & COMMENTARY

Sources: Imbimbo BP, et al. Efficacy and safety of epistigmine for the treatment of patients with AD. Neurology 1999;52(4):700-708; Kuhl DE, et al. In vivo mapping of cerebral acetylcholinesterase activity in aging and AD. Neurology 1999;52(4):691-699.

ALZHEIMER'S DISEASE (AD) PROGRESSES SLOWLY, necessitating many years to fully assess the efficacy of new treatments. One small step consists of the outcome of a randomized trial of epistigmine, yet another acetylcholinesterase inhibitor (AChEI) being tested for ameliorating AD-related dementia. Epistagmine given 15 mg tid previously showed marginal improvement in AD patients, but ...

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