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Article: Estrogen Supplementation Attenuates Glucocorticoid and Catecholamine Responses to Mental Stress in Perimenopausal Women.
- Article from:
- OB/GYN Clinical Alert
- Article date:
- April 1, 1999
CopyrightCOPYRIGHT 1999 A Thomson Healthcare Company. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Synopsis: Estrogen supplementation of hypoestrogenic perimenopausal women attenuated blood pressure, cortisol, and catecholamine responses to acute psychological challenge.
Source: Komesaroff PA, et al. J Clin Endocrinol Metab 1999;84:606-610.
THE PRESENT STUDY TESTED THE HYPOTHESIS THAT estradiol reduces cortisol and catecholamine responses to stress. Twelve women within two years of their last menses with hot flashes were designated as being perimenopausal. Women with known cardiovascular disease, including hypertension, were excluded. These women were then randomized to 12 weeks of estradiol valerate, 2 mg daily by mouth, or placebo. Outcome ...