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Article: Polycations/Cationic Lipids Enhance Adenovirus Transduction.
- Article from:
- Gene Therapy Weekly
- Article date:
- November 8, 1999
CopyrightCOPYRIGHT 1999 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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1999 NOV 8 - (NewsRx.com) -- Polycations and cationic lipids enhance adenovirus-mediated transduction and transgene expression in tumor cells, researchers from the United States reported.
"Replication-deficient adenovirus vectors are efficient vehicles for delivering therapeutic genes into mammalian cells," wrote P.R. Clark and colleagues, University Arizona, Arizona Cancer Center. "However, the high doses required to produce effective gene transfer in vivo can also cause unwanted cellular toxicity. To improve replication-deficient adenovirus transgene expression while minimizing adverse reactions, we have tested polycationic compounds for their ability to ...