Article: National Probability Samples in Studies of Low-Prevalence Diseases. Part II: Designing and Implementing the HIV Cost and Services Utilization Study Sample.

Objective. The design and implementation of a nationally representative probability sample of persons with a low-prevalence disease, HIV/AIDS.

Data Sources/Study Setting. One of the most significant roadblocks to the generalizability of primary data collected about persons with a low-prevalence disease is the lack of a complete methodology for efficiently generating and enrolling probability samples. The methodology developed by the HCSUS consortium uses a flexible, provider-based approach to multistage sampling that minimizes the quantity of data necessary for implementation.

Study Design. To produce a valid national probability sample, we combined a ...

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