Article: Applied chemistry.

NIGEL FREESTONE, University College Northampton

Chemosensors, small abiotic molecules that signal the presence of analytes, usually consist of a recognition site that binds the target substrate and a readout system that signals when this binding occurs. In the case of metal ion sensors, the recognition site is a metal-chelating molecule designed to bind the target ion selectively, while the readout system is very often a fluorophore. The two components are usually covalently linked through a spacer. Complexation of the metal ion results in a variation of the position and/or intensity of the emission band of the fluorophore. With this set-up, a large number of ...

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