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Article: SAQUINAVIR (Fortovase or Invirase).
- Article from:
- Research Initiative/Treatment Action!
- Article date:
- March 1, 2000
CopyrightCOPYRIGHT 2000 The Center for AIDS: Hope & Remembrance Project. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The 200 mg saquinavir soft-gel capsules are beige, opaque, soft gelatin capsules imprinted with "ROCHE" and "0246". Other formulations of saquinavir are available. Dosing may vary.
"Participants who drank one glass of grapefruit juice with the saquinavir, and then another glass an hour later saw their AUCs (areas under the curve, a measure of the total exposure of the drug) increase 50 percent to 150 percent. The AUC of saquinavir was increased to 220 percent when double-strength grapefruit juice was given. Despite such results, there could be some uncertainties or drawbacks in taking grapefruit juice [with] saquinavir to increase the efficacy of a low dose. ...