Article: Deep Brain Stimulation for Advanced Parkinson's Disease.

Parkinson's disease (PD) was first described in 1817 by James Parkinson, an English physician.(1) Parkinson's disease is an idiopathic, progressive, neurodegenerative disorder involving the loss of cells that produce the neurotransmitter dopamine in a part of the brain stem called the substantia nigra pars compacta.(2) It is manifested clinically by rigidity, bradykinesia, tremor, and postural instability.(3) Parkinson's disease is common, with an age-dependent prevalence ranging from one case per 1,000 people in middle-aged adults to 50 cases per 1,000 in the elderly. Table 1 lists a glossary of terms associated with PD.

Table 1

GLOSSARY OF TERMS

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