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Article: Tenascin Expression in Intraepithelial Neoplasia and Invasive Carcinoma of the Uterine Cervix.
- Article from:
- Archives of Pathology & Laboratory Medicine
- Article date:
- September 1, 2000
- Author:
CopyrightCOPYRIGHT 2000 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Tenascin (TN) is a large glycoprotein of the extracellular matrix that is transiently expressed in various tissues during embryogenesis and growth. It is also expressed in wound healing and tumor stroma.[1-3] Tenascin may have a role in cell adhesion, migration, and promotion of growth during fetal development and oncogenesis.[4-6]
The stroma and its extracellular matrix located in and around invasive tumors may show a desmoplastic reaction that differs morphologically from that of the normal stroma of the same organ. There is evidence that this desmoplastic reaction is related to tumor invasion and is the result of a derangement of cell-cell adhesion. Because TN ...