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Article: Excretion of Hexachlorobenzene and Metabolites in Feces in a Highly Exposed Human Population.
- Article from:
- Environmental Health Perspectives
- Article date:
- July 1, 2000
- Author:
CopyrightCOPYRIGHT 2000 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,485 ng/mL (mean [+ or -] SD, 124 [+ or -] 278), confirming that this human population has the highest HCB blood levels ever reported. All analyzed feces samples contained unchanged HCB (range, 11-3,025 ng/g dry weight; mean [+ or -] SD, 395 [+ or -] 629). The HCB concentration in feces strongly correlated with HCB in serum (r = 0.85; p [is less than] 0.001), ...