Article: Excretion of Hexachlorobenzene and Metabolites in Feces in a Highly Exposed Human Population.

A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,485 ng/mL (mean [+ or -] SD, 124 [+ or -] 278), confirming that this human population has the highest HCB blood levels ever reported. All analyzed feces samples contained unchanged HCB (range, 11-3,025 ng/g dry weight; mean [+ or -] SD, 395 [+ or -] 629). The HCB concentration in feces strongly correlated with HCB in serum (r = 0.85; p [is less than] 0.001), ...

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