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Article: Cancer Cells Walk the Tightrope.
- Article from:
- Cancer Weekly
- Article date:
- October 31, 2000
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2000 OCT 31 - (NewsRx.com) --
Researchers have shown that the well known tumor-suppressor gene p53 and its lesser-known cousin, p73, are controlled by the same activation switch.
Flipping the activation switch begins a process that can instruct a cell to stop growing or to die. As an activator of cell death, the switch may become the target of a new generation of anticancer therapies.
In the October 5, 2000, issue of the journal Nature, two Howard Hughes Medical Institute research teams show that a transcription factor called E2F-1 activates p53 and p73.
E2F-1 is a cancer-promoting gene, or oncogene. Mutations in the p53 gene are ...