Article: FINDING NEURONAL SOURCE OF UNCONTROLLED URINATION ROCHE NEUROPHARMACOLOGIST TESTS 'PIVOTAL' RECEPTOR CAUSING BLADDER INCONTINENCE IN MICE; AIM IS DRUG.

"When ya gotta go, ya gotta go!"

This informal rule of conduct expresses the truism that the urge to pass water - to urinate - simply cannot be denied.

A historic case in point concerns one of Renaissance Europe's greatest astronomers, the Danish stargazer Tycho Brache (1546- 1601). Late in life he was appointed astronomer royal to the emperor Rudolph II, who ran the Holy Roman Empire from his palace in Prague, Bohemia. At a royal banquet, Brache indulged mightily in wine (alcohol being a bladder stimulant), and felt a strong urge to urinate. But fearing to show disrespect to his monarch by a temporary absence from the royal presence, he kept his ...

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