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Article: Levels of Seven Urinary Phthalate Metabolites in a Human Reference Population.
- Article from:
- Environmental Health Perspectives
- Article date:
- October 1, 2000
- Author:
CopyrightCOPYRIGHT 2000 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Using a novel and highly selective technique, we measured monoester metabolites of seven commonly used phthalates in urine samples from a reference population of 289 adult humans. This analytical approach allowed us to directly measure the individual phthalate metabolites responsible for the animal reproductive and developmental toxicity while avoiding contamination from the ubiquitous parent compounds. The monoesters with the highest urinary levels found were monoethyl phthalate (95th percentile, 3,750 ppb, 2,610 [micro]g/g creatinine), monobutyl phthalate (95th percentile, 294 ppb, 162 [micro]g/g creatinine), and monobenzyl phthalate (95th percentile, 137 ppb, 92 ...