Article: Beta-Carotene: The Controversy Continues.

Abstract

The three [Beta]-carotene intervention trials: the Beta-Carotene and Retinol Efficacy Trial (CARET), Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC), and Physician's Health Study (PHS) have all pointed to a lack of effect of synthetic [Beta]-carotene in decreasing cardiovascular disease or cancer risk in well-nourished populations. The potential contribution of [Beta]-carotene supplementation to increased risk of lung cancer in smokers has been raised as a significant concern. The safety of synthetic [Beta]-carotene supplements and the role of isomeric forms of [Beta]-carotene (synthetic all-trans versus "natural" cis-trans isomeric ...

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