Article: Vitamin therapy produces regression of atherosclerosis.

One hundred-one patients (mean age, 53 years) with multiple risk factors for atherosclerosis, most of whom also had clinically manifest atherosclerosis, were treated daily with folic acid (2.5 mg), pyridoxine (25 mg), and cyanocobalamin (250 mcg). In 51 patients, the initial plasma homocyst(e)ine concentration was above 14 micromol/l, (a level commonly regarded as high enough to warrant treatment), and in 50 patients the concentration was below 14 micromol/l. Among patients with initial plasma homocyst(e)ine levels greater than 14 micromol/l, the mean rate of progression of carotid atherosclerosis (plaque area) was 0.21 cm2/year before vitamin therapy, and -0.049 cm2/year ...

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