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Article: The [Pl.sup.A] Polymorphism of Glycoprotein IIIa Functions as a Modifier for the Effect of Estrogen on Platelet Aggregation.
- Article from:
- Archives of Pathology & Laboratory Medicine
- Article date:
- January 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The progression of coronary heart disease (CHD) accelerates markedly after menopause, and this increase is at least partially due to the drop of endogenous estrogen production by the ovaries.[1] Therefore, it was hypothesized that hormone replacement therapy (HRT), through the reduction of risk factors for CHD, may decrease the incidence and/or progression of CHD in postmenopausal women.[2] However, HRT, when tested in double-blind, randomized, prospective secondary prevention studies resulted in an early increase in coronary events (Heart and Estrogen/Progestin Replacement Study),[3] while late benefit from HRT has been deemed unlikely.[4] Our inability to account for the ...