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Article: Lack of Evidence for Chloramphenicol Resistance in Neisseria meningitidis, Africa.
- Article from:
- Emerging Infectious Diseases
- Article date:
- January 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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To the Editor: High-level chloramphenicol resistance has been reported in 11 epidemiologically unrelated Neisseria meningitidis serogroup B strains in Vietnam and in a single strain in France, all isolated between 1987 and 1996 (1). Resistance was mediated by a chloramphenicol acetyltransferase (Cat) encoded by a catP gene homologous to Clostridium perfringens transposon Tn4451. While used infrequently in industrialized countries, chloramphenicol is often used to treat patients with meningococcal disease in Africa, especially during epidemics, when it frequently becomes the drug of choice because it can be administrated intramuscularly (2).
To evaluate the ...