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Article: Vitamin B6 and cardiovascular disease.
- Article from:
- Townsend Letter for Doctors and Patients
- Article date:
- April 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 The Townsend Letter Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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In a multicenter case-control study of 750 patients with vascular disease of the coronary, cerebral, or peripheral vessels and 800 control subjects, elevation of total homocysteine (tHcy) (above the 80th percentile) was found to be a risk factor for vascular disease in both women and men. In both sexes, low circulating levels of vitamin B6 (pyridoxal 5-phosphate) was associated with 2- to 3-fold increased risk of vascular disease, independent of tHcy levels.
Comment: Elevated tHcy is a known risk factor for cardiovascular disease. In a previous study (Am J Hypertens 2000;13:105-110), supplementation with vitamin B6, folic acid, and vitamin B12 reduced elevated ...
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