Article: Geron Corporation Announces Study Results Demonstrating the Utility of Telomerase Promoter-based therapies for cancer.

Article: Visualization of Telomerase Reverse Transcriptase (hTERT) ...
The Journal of Nuclear Medicine;  February 1, 2006 ;     700+ words ... ... imaging. Conclusion: hTERT promoter activity can be monitored ... hTERT expression in cancer cells may be clinically significant ... chemoresistance of cancer cells (7). Furthermore ... radionuclide imaging of hTERT promoter activity was recently ...

Article: KSHV LANA up-regulates hTERT promoter transcription ...
Blood Weekly;  December 9, 2004 ;     700+ words ... ... report. "We have previously shown that hTERT promoter activity is up-regulated by the Kaposi ... C. Verma and colleagues. "The hTERT promoter sequence located at positions -130 ... investigators said, "we demonstrate that hTERT promoter activity is due to the direct interaction ...

Article: hTERT promoter methylation in human primary ...
Journal of the Alabama Academy of Science;  April 1, 2003 ;     605 words ...Telomerase is an enzyme known to be important in chromosomal stability and cellular senescence. By maintaining sequences of 5'-TTAGGG-3' on the ends of chromosomes telomerase keeps cells resistant to aging and unaffected by the restrictions imposed on them by the Hayflick limit. The enzyme's

Article: Study Demonstrates Utility of Telomerase Promoter.(in ...
Biotech Week;  April 18, 2001 ;     700+ words ... ... Introduction of this hTERT promoter tk gene expression ... and pancreatic cancer cells caused the rapid ... results show that the hTERT promoter can be used successfully ... that will kill cancer cells. Moreover, the hTERT promoter can be used to ...

Article: Death receptor 4 kills breast cancer cells despite ...
Obesity, Fitness & Wellness Week;  December 4, 2004 ;     697 words ... ... from the United States, "breast cancer cells are generally resistant to induction ... relatively weak tumor-specific hTERT promoter, DR4 was less effective alone ... DR4) efficiently kills breast cancer cells irrespective of their sensitivity ...

Article: Adenovirus-mediated suicide gene therapy destroys ovarian ...
Cancer Gene Therapy Week;  January 19, 2004 ;     700+ words ... ... suicide gene therapy destroys ovarian cancer cells. "Telomerase is a ribonucleoprotein ... possibility of the utilization of the hTERT promoter in targeted cancer gene therapy ... University, Anam Hospital. "We cloned the hTERT promoter in the replace of the CMV promoter ...

Article: Bax gene therapy promotes apoptosis in pancreatic cancer ...
Gene Therapy Weekly;  October 3, 2002 ;     650 words ... ... might be attained in cancer cells growing in humans ... overexpressed in pancreatic cancer cells following gene transfer ... reverse transcriptase (hTERT) promoter, Bax gene therapy ... activity. Pancreatic cancer cells treated with control ...