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Article: Evaluation Of An Alternative Solid Dosage Form To Enteric Coated Pellets Containing Ibuprofen: A Case Of Study.(enteric-coated minitablets)(Statistical Data Included)
- Article from:
- Pharmaceutical Processing
- Article date:
- January 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 Advantage Business Media. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Introduction
Recent works have evaluated the potential of mini-tablets contained into hard gelatine capsules(3,4,5). In order to get the benefits and advantages of multiparticulate dosage forms, it is necessary for tablets of between 2 and 4 mm diameter to be used. Tablets larger than 4 mm could not be contained in a hard gelatin capsule in any great number as well as tablets smaller than 2 mm would be extremely difficult to manufacture. Studies have shown that tablets of this size have a similar emptying pattern to standard pellet formulation(6).
The demonstration of the feasibility to obtain Ibuprofen minitablets alternative to pellets was the ...