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Article: Ebola Virus Glycoprotein Demonstrates Differential Cellular Localization in Infected Cell Types of Nonhuman Primates and Guinea Pigs.
- Article from:
- Archives of Pathology & Laboratory Medicine
- Article date:
- May 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Ebola virus (EBOV) Zaire (EBOV-Z) has emerged as one of the deadliest pathogens known to affect humans. Outbreaks are sporadic but often explosive, causing lethal hemorrhagic disease with fatality rates of 70% to 90%.[1-3] Nonhuman primates (NHP) are also naturally infected with EBOV.[4-6] In addition to NHP, guinea pigs and mice can be infected experimentally,[7-9] making them useful animal models.
The pathogenesis of Ebola hemorrhagic fever is poorly understood. The characteristic pathologic features of infection in humans and NHP include multifocal hemorrhages, disseminated intravascular coagulation, and focal necrotizing lesions in multiple organs, including ...