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Article: HAM56-Immunoreactive Macrophages in Untreated Infiltrating Gliomas.(monoclonal antibody analysis in glioma diagnosis)
- Article from:
- Archives of Pathology & Laboratory Medicine
- Article date:
- May 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 College of American Pathologists. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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In surgical neuropathology, a potential diagnostic pitfall is the failure to recognize macrophages. Freezing artifact, inadequate processing of tissue, and reactive astrocytosis may distort the characteristic morphologic features of macrophages and make interpretation based on hematoxylin-eosin features alone challenging. Studies using a variety of monoclonal antibodies against operationally specific markers for macrophages have suggested that macrophages are present in tumors of the central nervous system (CNS) including astrocytomas, oligodendrogliomas, ependymomas, meningiomas, medulloblastomas, acoustic neuromas, craniopharyngiomas, hemangioblastomas, CNS lymphomas, ...