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Article: Acute Estrogen With or Without Progesterone No Help in Unstable Angina.
- Article from:
- Family Practice News
- Article date:
- May 15, 2001
- Author:
CopyrightCOPYRIGHT 2001 International Medical News Group. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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ORLANDO, FLA. -- Acute estrogen with or without progesterone doesn't curb recurrent myocardial ischemia in postmenopausal women with unstable angina, Dr. Steven P. Schulman re ported at the annual meeting of the American College of Cardiology.
He had hypothesized that it would, since endothelial dysfunction is a hallmark of unstable angina, and prior cardiac catheterization studies in postmenopausal women had shown that acute estrogen therapy causes coronary vasodilation, increased coronary blood flow, and reversal of acetylcholine-induced endothelial dysfunction.
In a clinical trial, 293 postmenopausal women on standard anti-ischemic therapy while ...