Article: DRUGS, PREGNANCY, AND LACTATION.

Antihistamines comprise a large, fairly diverse group of compounds that are so prevalent that many women are probably exposed to these drugs at some point during pregnancy.

In general, first-generation antihistamines are usually safe during pregnancy when used occasionally, but should not be used for frequent, chronic allergy symptoms. There is little human pregnancy information on second-generation antihistamines.

During the first trimester, it is best to avoid antihistamines. But if an antihistamine is indicated, the best option is the oral first-generation drug chlorpheniramine, which is marketed over the counter under several names, including ...

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