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Article: Glutamine.(therapeutic usage and analysis of glutamine metabolism)
- Article from:
- Alternative Medicine Review
- Article date:
- June 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 Thorne Research Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Glutamine. Labow BI, Souba WW. World J Surg 2000;24:1503-1513.
Relatively little was known about glutamine metabolism until the 1930s, when Sir Hans Krebs first demonstrated glutamine hydrolysis and biosynthesis in the kidney. Subsequent studies by Rose in 1938 demonstrated that glutamine is a nonessential (dispensable) amino acid, as it can be readily synthesized de novo in virtually all tissues in the body. Because the body has the capacity to synthesize considerable quantities of glutamine, it has been assumed that glutamine is not required in the diet. However, this amino acid becomes quite depleted during the course of a catabolic insult such as injury or ...