Article: Three-Dimensional Morphology of c-Kit--Positive Cellular Network and Nitrergic Innervation in the Human Gut.

Although it is now more than 100 years since Cajal described small fusiform cells with prominent nuclei as forming a network in the gastrointestinal tract, many questions about these cells remain unanswered.[1] In the human bowel, the interstitial cells of Cajal (ICCs) are localized at the level of the myenteric plexus between the longitudinal and circular muscle layers, in the deep muscular plexus in the innermost part of the circular muscle layer, and within the circular muscle layer itself.[2,3] Morphologic studies have suggested 3 major functions for ICCs: (1) as pacemaker cells in the muscles of the gastrointestinal tract, (2) as facilitators of active propagation of ...

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