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Article: Associations of Blood Pressure and Hypertension with Lead Dose Measures and Polymorphisms in the Vitamin D Receptor and [Delta]-Aminolevulinic Acid Dehydratase Genes.
- Article from:
- Environmental Health Perspectives
- Article date:
- April 1, 2001
- Author:
CopyrightCOPYRIGHT 2001 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Evidence suggests that lead and selected genes known to modify the toxicokinetics of lead--namely, those for the vitamin D receptor (VDR) and [Delta]-aminolevulinic acid dehydratase (ALAD)--may independently influence blood pressure and hypertension risk. We report the relations among ALAD and VDR genotypes, three lead dose measures, and blood pressure and hypertension status in 798 Korean lead workers and 135 controls without occupational exposure to lead. Lead dose was assessed by blood lead, tibia lead measured by X-ray fluorescence, and dimercaptosuccinic acid (DMSA)-chelatable lead. Among lead workers, 9.9% (n = 79) were heterozygous for the [ALAD.sup.2] allele, and ...