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Article: Attenuated Allergic Responses to House Dust Mite Antigen in Feed-Restricted Rats.
- Article from:
- Environmental Health Perspectives
- Article date:
- December 1, 2000
- Author:
CopyrightCOPYRIGHT 2000 National Institute of Environmental Health Sciences. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Caloric restriction has been shown to alter a broad range of immunological end points in both experimental animals and humans. The objective of this study was to investigate the effect of short-term moderate feed restriction (25% reduction) on allergic immune responses in Brown Norway rats. After 3 weeks of acclimation to their feed regimens, rats were sensitized and 2 weeks later challenged with house dust mite (HDM) antigen via intratracheal instillation. Feed restriction resulted in lower levels of antigen-specific IgE in serum and reduced antigenspecific lympho-proliferative activity in pulmonary lymph nodes. Feed restriction also attenuated pulmonary inflammation, as ...
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